From December of 1994 to April of 1995, we, SNUH Department of pediatric Thoracic and Cardiovascular Surgery, studied effects of aprotinin. 95 patients were randomly divided into two groups: group I (n=47) with aprotinin and group II (n=48)
without
aprotinin.
Aprotinin was given as one shot injection to cardiopulmonary bypass perfusion solution with dose of 50,000 KIU/kg. Laboratory data such as hemohlobin, hematocrit, BUN, creatinine, fibrinogen, electrolyte concentration, aPTT, PT, and AT III was
checked
preoperatively. 5 minutes after anesthesia. 5 minutes and 35 minutes after CPB circulation, and 5 minutes, 3 hours, and 24 hours after reperfusion. Also, chest-tube drainage, transfused amount of RBC, platelet concentrate, and fresh frozen plasma
within
first 24 hours postoperatively were checked and analyzed after transition on body weight demension.
Only RBC transfused postoperatively had statistical significance with P value of less than 0.001. Others had no difference statistical wise. Postoperative side effects of aprotinin was not detected weeks after the surgery and there was no
reoperated
patient due to postoperative bleeding .
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